Engineering induction of singular neural rosette emergence within hPSC-derived tissues
Human pluripotent stem cell (hPSC)-derived neural Network Signal Extend Wire organoids display unprecedented emergent properties.Yet in contrast to the singular neuroepithelial tube from which the entire central nervous system (CNS) develops in vivo, current organoid protocols yield tissues with multiple neuroepithelial units, a.k.a.neural rosettes